WHAT WE TREAT

DISEASES & PRODUCTS

Innovative Treatments for a Range of Diseases

Salix is a specialty pharmaceutical company that offers innovative treatments for gastrointestinal (GI) diseases. For almost 30 years, we have licensed, developed, and marketed products to provide healthcare professionals and patients with effective solutions for the management of conditions such as hepatic encephalopathy, irritable bowel syndrome with diarrhea, opioid-induced constipation, and ulcerative colitis.

Read more about these chronic and debilitating conditions:

Hepatic Encephalopathy (HE)

HE is a brain dysfunction caused by liver insufficiency and/or portal systemic shunting.1

Because a damaged liver cannot function normally (as in cirrhosis), toxins from the gut can enter the bloodstream and travel to the brain, where they affect neurotransmission. This can cause episodes of HE, which may present as alterations in consciousness, cognition, and behavior that range from minimal to severe.1-3

Overt HE occurs in 30% to 40% of patients with cirrhosis at some point during the clinical course of their disease.1 As the burden of chronic liver disease and cirrhosis is increasing, the frequency of HE is also increasing.4,5

Learn more about treatments for HE.

Irritable Bowel Syndrome With Diarrhea (IBS-D)

IBS-D is a common disorder of the large intestine (colon).6 It affects more than 25 million Americans, about twice as many women as men.7 The symptoms of IBS-D can happen on a regular basis and vary widely, but often include abdominal pain and diarrhea.7

The cause of IBS-D is unknown, but may result from a disturbance in the way the gut, brain, and nervous system interact.7

Learn more about treatments for IBS-D.

Opioid-induced Constipation (OIC)

Constipation may be defined as having one or more symptoms: hard stools, infrequent stools, the need for excessive straining, the sense of incomplete bowel evacuation, and excessive time spent on the toilet or in unsuccessful defecation.8

Constipation can also be classified by etiology:

  • Primary constipation9
    • Results from intrinsic defects of colonic or anorectal function
    • Considered typically after secondary causes have been ruled out
  • Secondary constipation9
    • Caused by pathologic changes, such as disease or intestinal obstruction
    • Caused by medications (iatrogenic), such as opioids

Constipation is a frequent side effect of opioids10-13

  • Opioids are a major class of analgesics often used to relieve pain11
  • One of the most common side effects of opioids is constipation, with incidence ranging from 40% to 80%10,12,13

Learn more about treatments for OIC.

Ulcerative Colitis (UC)14

UC is a disease that causes inflammation in the colon, which can lead to bleeding, production of pus, diarrhea, and abdominal or stomach discomfort. Over 900,000 Americans have UC, and it equally affects men and women.

UC is chronic, with no known cure. It is a type of inflammatory bowel disease (IBD), not to be confused with irritable bowel syndrome (IBS), which does not cause inflammation in the colon.

Learn more about treatments for UC.

APRISO®

(mesalamine) 0.375 g extended-release capsules

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CYCLOSET®

(bromocriptine mesylate) 0.8 mg tablets

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MOVIPREP®

(PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate and ascorbic acid) 100 g/7.5 g/2.691 g/1.015 g/5.9 g/4.7 g for oral solution

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RELISTOR®

(methylnaltrexone bromide) 8 mg/12 mg subcutaneous injection

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RELISTOR®

(methylnaltrexone bromide) 150 mg tablets

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UCERIS®

(budesonide) 9 mg extended-release tablets

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UCERIS®

(budesonide) 2 mg rectal foam

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ANUSOL®-HC

(hydrocortisone) 2.5% cream

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ANUSOL®-HC

(hydrocortisone acetate) 25 mg suppository

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APRISO®

(mesalamine) 0.375 g extended-release capsules

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AZASAN®

(azathioprine) 75/100 mg tablets

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COLAZAL®

(balsalazide disodium) 750 mg capsules

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CYCLOSET®

(bromocriptine mesylate) 0.8 mg tablets

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DEFLUX®

(hyaluronic acid/dextranomer)

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DIURIL®

(chlorothiazide) 250 mg oral suspension

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FENOGLIDE®

(fenofibrate) 48/145 mg tablets

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GIAZO®

(balsalazide disodium) 1.1 g tablets

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GLUMETZA®

(metformin) 500/1000 mg tablets

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METOZOLV® ODT

(metoclopramide HCl) 5 mg orally disintegrating tablets

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MOVIPREP®

(PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate and ascorbic acid) 100 g/7.5 g/2.691 g/1.015 g/5.9 g/4.7 g for oral solution

Patient Website >
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OSMOPREP®

(sodium phosphate monobasic monohydrate, USP, and sodium phosphate dibasic anhydrous, USP) tablets

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PEPCID®

(famotidine) for oral suspension

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PEPCID®

(famotidine) 20/40 mg tablets

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PROCTOCORT ®

(hydrocortisone) 1% cream

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PROCTOCORT ®

(hydrocortisone acetate) 30 mg suppository

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RELISTOR®

(methylnaltrexone bromide) 8 mg/12 mg subcutaneous injection

Patient Website >
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Prescribing Information >

RELISTOR®

(methylnaltrexone bromide) 150 mg tablets

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SOLESTA®

(hyaluronic acid/dextranomer)

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UCERIS®

(budesonide) 9 mg extended-release tablets

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UCERIS®

(budesonide) 2 mg rectal foam

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XIFAXAN®

(rifaximin) 200 mg tablets

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ZEGERID®

(omeprazole/sodium bicarbonate) 20/40 mg capsules

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ZEGERID®

(omeprazole/sodium bicarbonate) 20/40 mg omeprazole and 1680 mg sodium bicarbonatepowder for oral suspension

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Giving Patients More

More information and support through special programs

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Fostering HCP Relationships

Committed to connecting with healthcare professionals (HCPs)

See HCP Focus
References: 1. Vilstrup H, Amodio P, Bajaj J, et al. Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology. 2014;60(2):715-735. 2. Neff GW, Kemmer N, Duncan C, Alsina A. Update on the management of cirrhosis—focus on cost-effective preventative strategies. Clin Econ Outcomes Res. 2013;5:143-152. 3. Blei A, Cordoba J; The Practice Parameters Committee of the American College of Gastroenterology. Hepatic encephalopathy. Am J Gastroenterol. 2001;96(70):1968-1976. 4. Frederick RT. Current concepts in the pathophysiology and management of hepatic encephalopathy. Gastroenterol Hepatol. 2011;7(4):222-233. 5. Peery AF, Crockett SD, Barritt AS, et al. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterol. 2015;147:1731-1741. 6. Mayo Clinic. Irritable bowel syndrome. http://www.mayoclinic.org/diseases-conditions/irritable-bowel-syndrome/basics/definition/con-20024578. Accessed February 27, 2017. 7. International Foundation for Functional Gastrointestinal Disorders (IFFGD). Facts about IBS. http://www.aboutibs.org/facts-about-ibs.html. Accessed February 27, 2017. 8. Lembo A, Camilleri M. Chronic constipation. N Engl J Med. 2003;349(14):1360-1368. 9. Andrews CN, Storr M. The pathophysiology of chronic constipation. Can J Gastroenterol. 2011;25(suppl B):16B-21B. 10. Sharma A, Jamal MM. Opioid induced bowel disease: a twenty-first century physicians' dilemma. Curr Gastroenterol Rep. 2013;15(7):334. 11. Vanegas G, Ripamonti C, Sbanotto A, De Conno F. Side effects of morphine administration in cancer patients. Cancer Nurs. 1998;21(4):289-297. 12. Bell TJ, Panchal SJ, Miaskowski C, Bolge SC, Milanova T, Williamson R. The prevalence, severity, and impact of opioid-induced bowel dysfunction: results of a US and European patient survey (PROBE 1). Pain Med. 2009;10(1):35-42. 13. Kalso E, Edwards JE, Moore RA, McQuay HJ. Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Pain. 2004;112(3):372-380. 14. Crohn’s & Colitis Foundation. What is ulcerative colitis? http://www.crohnscolitisfoundation.org/what-are-crohns-and-colitis/what-is-ulcerative-colitis/. Accessed February 27, 2017.