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MoviPrep - PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate and ascorbic acid for oral solution


Importance of
Bowel Prep

Importance of bowel prep

This information is intended for U.S. Healthcare Professionals only.

Colorectal cancer (CRC) is the second leading cause of cancer–related death. Fortunately, it can be prevented 9 out of 10 times through early detection with colonoscopy.1 Unfortunately, up to 30% of bowel preparations are inadequate, hindering detection of small and flat lesions.2

A clean colon is necessary to identify polyps and lesions, including flat lesions, which are 10 times more likely to be cancerous than polyps. Excellent cleansing is also necessary but difficult to achieve in the ascending colon, where about 37% of flat lesions are found.3 In addition to achieving excellent colon cleansing, an effective prep should maximize tolerability and compliance.

Timing is another key to achieving a clean colon. Recent guidelines from the American College of Gastroenterology recommend split dosing with at least half of the dose given on the day of the colonoscopy for optimal visualization of the ascending colon and cecum, improving the quality of bowel preparations and colonoscopy.4,5

MoviPrep delivers consistent visibility throughout the colon

MoviPrep is a low–volume PEG that is proven in 89% of patients to provide good or excellent cleansing in the entire colon.6 MoviPrep is proven more tolerable than 4–L PEG solutions, and 9 out of 10 patients would take MoviPrep again for their next procedure.6,7 MoviPrep is also the first and only PEG bowel preparation indicated for PM/AM Split Dosing™.

References:

  1. Colon cancer screening. American Society for Gastrointestinal Endoscopy Web site. http://www.asge.org/pressroomindex.aspx?id=552. Accessed June 30, 2009.
  2. Cohen LB, Tennyson C. Bowel preparation for colonoscopy: maximizing efficacy, minimizing risk. Gastroenterol Endosc News. 2007;5(special edition):23–31.
  3. Soetikno RM, Kaltenbach T, Rouse RV, et al. Prevalence of nonpolypoid (flat and depressed) colorectal neoplasms in asymptomatic and symptomatic adults. JAMA. 2008;299:1027–1035.
  4. Rex DK, Johnson DA, Anderson DA, Schoenfeld PS, Burke CA, Inadomi JM. American College of Gastroenterology guidelines for colorectal cancer screening 2008. Am J Gastroenterol. 2009;104:739–750.
  5. Khan MA, Wasiuddin N, Brown M. Patient acceptance, convenience and efficacy of one–day versus two–day colonoscopy bowel preparation. Poster presented at: Digestive Disease Week; May 17–22, 2008; San Diego, CA.
  6. MoviPrep [prescribing information]. Morrisville, NC: Salix Pharmaceuticals, Inc.; 2009.
  7. Data on file. Salix Pharmaceuticals, Inc.


MOVIPREP® (PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate and ascorbic acid for oral solution) is indicated for cleansing of the colon as a preparation for colonoscopy in adults 18 years of age or older. MOVIPREP is contraindicated in patients who have had a severe hypersensitivity reaction to any of its components. MOVIPREP should be used with caution in patients using concomitant medications that increase the risk of electrolyte abnormalities, in patients with known or suspected hyponatremia, severe ulcerative colitis, ileus, gastrointestinal obstruction or perforation, gastric retention, toxic colitis, toxic megacolon, or glucose-6-phosphate dehydrogenase deficiency. In clinical trials, abdominal distention, anal discomfort, thirst, nausea, and abdominal pain were the most common adverse reactions to MOVIPREP administration. MOVIPREP contains a maximum of 2.33 mg of phenylalanine per treatment.

Consult with your physician to see if this product is right for you.

For complete Prescribing Information, please click here.


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  • MoviPrep Product Prescribing Information